Common RNA pathway found in ALS and dementia

ScienceDaily (Sep. 30, 2012) ? Two proteins previously found to contribute to ALS, also known as Lou Gehrig's disease, have divergent roles. But a new study, led by researchers at the Department of Cellular and Molecular Medicine at the University of California, San Diego School of Medicine, shows that a common pathway links them.

The discovery reveals a small set of target genes that could be used to measure the health of motor neurons, and provides a useful tool for development of new pharmaceuticals to treat the devastating disorder, which currently has no treatment or cure.

Funded in part by the National Institutes of Health and the California Institute for Regenerative Medicine (CIRM), the study will be published in the advance online edition of Nature Neuroscience on September 30.

ALS is an adult-onset neurodegenerative disorder characterized by premature degeneration of motor neurons, resulting in a progressive, fatal paralysis in patients.

The two proteins that contribute to the disease -- FUS/TLS and TDP-43 -- bind to ribonucleic acid (RNA), intermediate molecules that translate genetic information from DNA to proteins. In normal cells, both TDP-43 and FUS/TLS are found in the nucleus where they help maintain proper levels of RNA. In the majority of ALS patients, however, these proteins instead accumulate in the cell's cytoplasm -- the liquid that separates the nucleus from the outer membrane, and thus are excluded from the nucleus, which prevents them from performing their normal duties.

Since the proteins are in the wrong location in the cell, they are unable to perform their normal function, according to the study's lead authors, Kasey R. Hutt, Clotilde Lagier-Tourenne and Magdalini Polymenidou. "In diseased motor neurons where TDP-43 is cleared from the nucleus and forms cytoplasmic aggregates," the authors wrote, "we saw lower protein levels of three genes regulated by TDP-43 and FUS/TLS. We predicted that this, based on our mouse studies, and found the same results in neurons derived from human embryonic stem cells."

In 2011, this team of UC San Diego scientists discovered that more than one-third of the genes in the brains of mice are direct targets of TDP-43, affecting the functions of these genes. In the new study, they compared the impact of the FUS/TLS protein to that of TDP-43, hoping to find a large target overlap.

"Surprisingly, instead we saw a relatively small overlap, and the common RNA targets genes contained exceptionally long introns, or non-coding segments. The set is composed of genes that are important for synapse function," said principal investigator Gene Yeo, PhD, assistant professor in the Department of Cellular and Molecular Medicine and the Institute for Genomic Medicine at UC San Diego and a visiting professor at the Molecular Engineering Laboratory in Singapore. "Loss of this common overlapping set of genes is evidence of a common pathway that appears to contribute to motor neuron degeneration."

In an effort to understand the normal function of these two RNA binding proteins, the scientists knocked down the proteins in brains of mice to mimic nuclear clearance, using antisense oligonucleotide technology developed in collaboration with ISIS Pharmaceuticals. The study resulted in a list of genes that are up or down regulated, and the researchers duplicated the findings in human cells.

"If we can somehow rescue the genes from down regulation, or being decreased by these proteins, it could point to a drug target for ALS to slow or halt degeneration of the motor neurons," said Yeo.

These proteins also look to be a central component in other neurodegenerative conditions. For example, accumulating abnormal TDP-43 and FUS/TLS in neuronal cytoplasm has been documented in frontotemporal lobar dementia, a neurological disorder that has been shown to be genetically and clinically linked to ALS, and which is the second most frequent cause of dementia after Alzheimer's disease.

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Story Source:

The above story is reprinted from materials provided by University of California - San Diego, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Clotilde Lagier-Tourenne, Magdalini Polymenidou, Kasey R Hutt, Anthony Q Vu, Michael Baughn, Stephanie C Huelga, Kevin M Clutario, Shuo-Chien Ling, Tiffany Y Liang, Curt Mazur, Edward Wancewicz, Aneeza S Kim, Andy Watt, Sue Freier, Geoffrey G Hicks, John Paul Donohue, Lily Shiue, C Frank Bennett, John Ravits, Don W Cleveland, Gene W Yeo. Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. Nature Neuroscience, 2012; DOI: 10.1038/nn.3230

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/25QVm4Je7AQ/120930142108.htm

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6th Annual Bark in the Park | WTVR.com ? Richmond News ...

(WTVR) ? It is your chance to help homeless animals in our area.

This morning the Henrico Humane Society is partnering with the county parks and rec for the 6th year to provide a day of fun for you and your dog.

Bark in the Park is going on at Dorey Park in the County?s east end.

Source: http://wtvr.com/2012/09/29/6th-annual-bark-in-the-park/

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Patient selection for bilateral total knee replacement needs improvement

ScienceDaily (Sep. 28, 2012) ? Because there are more risks with having a total knee replacement in both legs at the same time than having a knee replacement in one leg, doctors in recent years have been selecting younger and healthier patients for the bilateral procedure. Now a new study by researchers at Hospital for Special Surgery has revealed that although patients are younger and healthier than those undergoing only one-sided surgery, they are becoming sicker and some complication rates have risen.

"Although we are selecting younger people, we can't ignore the fact that the population in general is getting sicker," said Stavros Memtsoudis, M.D., Ph.D., director of Critical Care Services at Hospital for Special Surgery (HSS) in New York City, who led the study. "Many of the complications that we studied didn't decrease over time as you would expect with younger patients and better health care, and some of the complications even increased." The study is published online ahead of print in the journal Clinical Orthopaedics and Related Research.

Rising levels of obesity appear to be driving the complication rates, as well as the increase in the utilization of total knee replacements. Obesity puts extra stress on joints and bones and can cause premature osteoarthritis.

To conduct their research into trends regarding bilateral total knee replacements, researchers at HSS turned to the Nationwide Inpatient Survey, sponsored by the Agency for Healthcare Research and Quality (AHRQ). This is the largest inpatient database available in the United States that includes information on patients of all ages. It collects data from about 20% of all hospitalizations in the U.S. The study investigators identified 258,524 bilateral total knee replacements performed between 1999 and 2008. The number of annual bilateral procedures increased by 75%. In 1999, bilateral procedures accounted for 3.7% of all knee replacement operations and in 2008, they accounted for 6% of the operations.

The average age of patients undergoing bilateral knee replacement decreased by 2.5 years from 1999 to 2008. As the years marched on, patients presented with higher rates of comorbidities, including renal failure, neurologic disease, liver disease, diabetes, and chronic obstructive pulmonary disease. Obesity increased by 131% during the study period. The only comorbidity that decreased was congestive heart failure.

Over the time period studied, the researchers identified a 3% increase in pneumonia, a 6% increase in pulmonary embolism, and a 3% increase in nonmyocardial infarction cardiac complications.

"The take home message of this paper is that we are fighting an uphill battle, because people are getting sicker, despite us attempting to limit risk by choosing younger people to do these procedures in," said Dr. Memtsoudis. "We have to start thinking of other interventions other than patient selection that we can implement in order to reduce these complications."

On a positive note, the investigators also found that absolute in-hospital mortality rates decreased at an average rate of 10% per year. The researchers attribute this decrease to advances in medicine and increased use of telemetry and observation in the last 10 to 15 years. "With advances in medicine and monitoring, we have been able to counteract this extreme event of mortality. If you get a complication and it is not recognized, you may die from it," said Dr. Memtsoudis. "If you observe people more thoroughly, you may not be able to prevent the complication, but you may be able to prevent a mortal event resulting from it."

The researchers also identified a cost shifting landscape. Patients stayed in the hospital an average of five days after their procedure in 1999 and an average of four days in 2008, but the proportion of discharges to a home or customary residence without home health care decreased at an average rate of 5.5% per year.

"Before this study, we were under the assumption that patient complications were steadily decreasing after bilateral knee arthroplasty, because of better patient selection and improvements in medical care," said Dr. Memtsoudis. "Now we understand that the picture is more complex. Patients being selected for the procedure may be getting younger, but they are not getting healthier and maybe that is why we don't see a drastic drop in complications."

Before embarking on a bilateral knee replacement, he said, patients should "critically look at themselves and talk to their physicians about how their health status plays into the choice of surgery."

More work is needed to identify ways to prevent complications in patients undergoing bilateral knee replacement and a recent conference sponsored by the Hospital for Special Surgery is aiming to do just that. The Consensus Conference on the Creation of Guidelines for Bilateral Knee Arthroplasty involved 40 experts from 16 institutions. The guidelines coming out of this conference, which are expected to be published within the next six months, address issues such as determining the appropriate workup and management for a patient undergoing bilateral knee replacement, and how long doctors should wait between procedures if a patient undergoes two operations.

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Story Source:

The above story is reprinted from materials provided by Hospital for Special Surgery, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Stavros G. Memtsoudis, Carlos B. Mantilla, Javad Parvizi, Ottokar Stundner, Madhu Mazumdar. Have Bilateral Total Knee Arthroplasties Become Safer?: A Population-Based Trend Analysis. Clinical Orthopaedics and Related Research?, 2012; DOI: 10.1007/s11999-012-2608-9

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/aTlkoVATYFQ/120929140401.htm

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Virtually All General Automotive Repairs In A Single Auto Repair ...

You want to look for a motorized vehicle repair shop, if you need to keep your automotive well maintained and at a proper working issue. And even if you think finding a trusted auto repair shop together with a good mechanic may be a difficult activity, it really isn?t discover what to find. Pertaining to him, your negative thinking means you?re anxious about the car?s condition, so he will convince someone to get other companies, thus increasing vehicle repair cost. ?How is it possible get the perfect step stool for the shop? Sad to express, automotive transmission repair becomes a lot more expensive if the car owner does not necessarily know much over it and falls feed to unscrupulous motor vehicle service mechanics. Dirty air flow filters decrease gasoline economy and results, and can at times be blown-out along with a high-pressure air hose rather than replaced. The search gets paid the whole amount within 72 hours plus the consumer can finance the total amount up to 12 many months.

This could possibly vary on your experience given that you work for just a small body go shopping or an insurance vendor. . A motorized vehicle is undoubtedly an important component of the our existence. In place of insisting on a pre-repair try out, the mechanic tried out his best to obtain the cause of that noise to absolutely no avail. Many claims have laws requiring having hands-free cell phone technology in your car so head buds, car chargers, and cell phone holders with the car are well liked consumer items. When you?re new to automobile repair, these may assist you a lot. There are many common malfunctions with the brakes that automatic mechanics typically check out.

Your California Bureau involving Automotive Repair welcomes around 25, 000 auto repair complaints per annum. You might want to, therefore, find yourself an experienced and trustworthy automobile service mechanic no one can do excellent analysis work and car or truck repair, including complicated auto transmission, engine and brakes maintenance and simple automotive AC repair, while also educating you concerning automotive transmission repair services you would like for your Tampa automobile. If a motorized vehicle service shop practical knowledge in handling all these, you will wear good hands. Renting an automobile is your smart choice if it should take few days to finish the same task. Central Motive Power Incorporated (21) (505) 884-2525 3740 Princeton Dr NE ? Albuquerque, NM 87107. You will be really lucky more than enough because Chevrolet has reputation greater than hundred years with providing trusted trucks. For a fantastic touch, add that you?re certain you will have their services when you need it.

You may see specialty repair that performs a variety of forms of revive work. The Motor service and Repair Companies which are used more often are stored with greater regularity. Considering the introduction of analysis computers, the average lad in his garage doesn?t stand an occasion against many situations. Even thirty issue, cars were a great deal more analog than they?re today. Not necessarily reliable, and often functionality just isn?t guaranteed. With repair center software, you can acquire repair orders in the car using the handheld scanner. They in addition offer Auto Professionals the chance to use their site at no cost for 3 months to learn the benefits.

We have a standard called Mitchell Estimate Guides which can be used in vehicle repair shops. This might also mean a leak during the brake system, which can as well cause brake fail. Automobile repair guides in addition have information on motor insurance, car rentals, driving schools plus car washes. It is actually sad to see many shops with amazing potential waste money mainly because of the ineffective vehicle repair advertising they will use. Don?t pull into among those small dingy filling stations with rusty cars strewn about the property. To avoid any kind of automotive emergency, choosing the best S . fransisco Car Repairing and also Maintenance Company might be must.

If you are currently on the look out for more in-depth information regarding auto repair spokane wa, check out our website for more details.

Source: http://www.ilovegingers.com/2012/09/28/virtually-all-general-automotive-repairs-in-a-single-auto-repair-browse-in-bradenton-34207/

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My Town: Internet Auction of Surplus Property | FOX8.com ...

Posted on: 11:24 am, September 28, 2012, by Jennifer Winot, updated on: 11:37am, September 28, 2012

LAKE COUNTY, Ohio ? Audio visual, office and landscaping equipment, vehicles and more will be for sale during Lake Metroparks? sixth online auction.

The auction begins September 29 and will continue for a minimum of 15 days.

Potential bidders must make an appointment if they wish to inspect items prior to bidding. Items are located throughout the park district, so bidders need to contact Purchasing Manager Mark Evangelista at (440)639-7275 to make arrangements.

All items will be offered for sale ?as is, where is? with Lake Metroparks making no guarantee as to the condition of the items.

Buyers must pay within 10 business days and be responsible for removal of all items within 10 business days of the close of the auction.

Bidders may view and bid on items at the Lake Metroparks? auction website www.lmpauction.com.

Source: http://fox8.com/2012/09/28/my-town-internet-auction-of-surplus-property/

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Major League Baseball standings/box scores

All Hawaii times

American League

East Division

W L Pct GB

New York 91 66 .580 ?

Baltimore 90 67 .573 1

Tampa Bay 86 71 .548 5

Boston 69 88 .439 22

Toronto 69 88 .439 22

Central Division

Detroit 84 73 .535 ?

Chicago 83 74 .529 1

Kansas City 70 87 .446 14

Cleveland 66 91 .420 18

Minnesota 66 91 .420 18

West Division

Texas 92 65 .586 ?

Oakland 89 68 .567 3

Los Angeles 87 70 .554 5

Seattle 73 84 .465 19

Friday

Baltimore 9, Boston 1

Cleveland 8, Kansas City 5

N.Y. Yankees 11, Toronto 4

L.A. Angels 7, Texas 4

Minnesota 4, Detroit 2

Chicago White Sox 3, Tampa Bay 1

Oakland 8, Seattle 2

Today

N.Y. Yankees (Pettitte 5-3) at Toronto (R.Romero 9-14), 7:07 a.m.

Detroit (Verlander 16-8) at Minnesota (Walters 2-4), 1:05 p.m.

L.A. Angels (E.Santana 9-12) at Texas (D.Holland 11-6), 1:05 p.m.

Seattle (Vargas 14-11) at Oakland (Straily 2-1), 1:05 p.m.

Tampa Bay (M.Moore 10-11) at Chicago White Sox (Sale 17-7), 1:05 p.m.

Boston (Doubront 11-9) at Baltimore (S.Johnson 4-0), 1:05 p.m.

Kansas City (Odorizzi 0-1) at Cleveland (J.Gomez 5-8), 1:05 p.m.

Angels 7, Rangers 4

Los Angeles Texas

ab r h bi ab r h bi

Trout cf-lf 5 1 2 1 Kinsler 2b 3 1 0 0

TrHntr rf 3 1 0 0 Andrus ss 4 0 1 0

Pujols 1b 3 0 0 0 Hamltn cf 4 1 1 0

KMorls dh 4 1 1 1 Beltre 3b 4 1 2 2

Calhon ph-dh 1 0 0 0 N.Cruz rf 3 1 3 2

Callasp 3b 5 0 1 0 MiYong 1b 3 0 0 0

HKndrc 2b 4 2 2 1 DvMrp lf 3 0 0 0

Aybar ss 5 1 1 0 Napoli dh 4 0 0 0

Trumo lf 4 0 3 3 Soto c 2 0 0 0

Bourjos pr-cf 0 0 0 0 LMartn ph 1 0 0 0

Iannett c 3 1 1 1 LMrtnz c 0 0 0 0

Totals 37 7 11 7 Totals 31 4 7 4

Los Angeles 101 101 300?7

Texas 000 100 120?4

DP?Texas 1. LOB?Los Angeles 9, Texas 4. 2B?K.Morales (25), Trumbo 2 (18), Hamilton (29), N.Cruz (43). 3B?Trout (7). HR?Trout (29), Iannetta (9), Beltre (36), N.Cruz (23). SB?H.Kendrick (14). SF?N.Cruz.

IP H R ER BB SO

Los Angeles

Weaver W,20-4 7 5 2 2 2 5

Jepsen 1 2 2 2 1 1

Frieri S,22-25 1 0 0 0 0 0

Texas

Dempster L,7-3 5 2-3 7 4 4 4 7

R.Ross 1 2 3 3 1 1

Scheppers 1-3 2 0 0 0 0

Font 1 0 0 0 1 1

Uehara 1 0 0 0 0 2

WP?Font.

Umpires?Home, Jim Reynolds; First, James Hoye; Second, Jim Joyce; Third, Alan Porter.

T?3:14. A?46,662 (48,194).

Athletics 8, Mariners 2

Seattle Oakland

ab r h bi ab r h bi

Ackley 2b 5 0 1 0 Crisp cf 5 3 3 1

C.Wells rf 2 0 0 0 Drew ss 3 2 1 2

Seager 3b 4 0 1 0 Cespds lf 3 1 0 1

JMontr dh 3 0 0 0 Moss 1b 3 0 0 0

Jaso c 3 0 1 0 Reddck rf 4 0 1 0

Smoak 1b 4 0 1 0 Dnldsn 3b 4 0 1 2

MSndrs cf 3 1 1 1 S.Smith dh 2 0 0 0

TRonsn lf 4 1 1 1 JGoms ph-dh 2 0 0 0

Ryan ss 4 0 0 0 Kottars c 4 0 0 0

Pnngtn 2b 3 2 1 0

Totals 32 2 6 2 Totals 33 8 7 6

Seattle 010 000 100?2

Oakland 102 010 40x?8

E?Ryan (10), Ackley (8). DP?Oakland 1. LOB?Seattle 8, Oakland 6. 2B?Crisp (22). HR?M.Saunders (18), T.Robinson (3), Crisp (11), Drew (5).

IP H R ER BB SO

Seattle

Beavan L,10-11 4 2-3 4 4 3 2 2

O.Perez 2-3 1 0 0 0 0

Kelley 2-3 0 0 0 0 2

Furbush 0 1 3 2 2 0

Pryor 1-3 1 1 1 1 0

Noesi 1 2-3 0 0 0 0 3

Oakland

Griffin W,7-1 5 2-3 4 1 1 2 4

Doolittle H,15 1 1-3 1 1 1 0 0

Blevins 1 0 0 0 1 0

J.Miller 1 1 0 0 1 1

Furbush pitched to 3 batters in the 7th.

HBP?by Griffin (Jaso). WP?Furbush. PB?Jaso, Kottaras.

Umpires?Home, Eric Cooper; First, Marty Foster; Second, Jeff Kellogg; Third, Mike Winters.

T?3:00. A?16,376 (35,067).

Twins 4, Tigers 2

Detroit Minnesota

ab r h bi ab r h bi

AJcksn cf 4 1 0 0 Span cf 3 1 1 0

Infante 2b 4 1 1 2 Revere rf 3 0 0 0

MiCarr 3b 4 0 2 0 Mauer c 2 1 0 0

Fielder 1b 4 0 1 0 Mornea 1b 3 1 0 0

DYong dh 4 0 2 0 Doumit dh 4 1 2 4

JhPerlt ss 4 0 0 0 Mstrnn pr-dh 0 0 0 0

Dirks lf 4 0 0 0 Plouffe 3b 4 0 0 0

AGarci rf 3 0 0 0 JCarrll 3b 0 0 0 0

G.Laird c 3 0 0 0 MCarsn lf 4 0 0 0

EEscor 2b 2 0 1 0

ACasill 2b 0 0 0 0

Flormn ss 3 0 0 0

Totals 34 2 6 2 Totals 28 4 4 4

Detroit 000 000 020?2

Minnesota 000 000 22x?4

E?Fielder (11), Morneau (6), Plouffe (17). LOB?Detroit 5, Minnesota 6. 2B?Doumit (34). HR?Infante (4), Doumit (17). SB?Span (17). S?Revere.

IP H R ER BB SO

Detroit

Smyly 5 1-3 2 0 0 1 5

Coke 2-3 1 2 1 0 1

Dotel 1 0 0 0 0 0

B.Villarreal L,3-5 1 1 2 2 3 2

Minnesota

Diamond 7 1-3 6 2 1 0 1

Burton W,3-1 2-3 0 0 0 0 1

Perkins S,16-19 1 0 0 0 0 0

Coke pitched to 2 batters in the 7th.

HBP?by Dotel (E.Escobar).

Umpires?Home, Ron Kulpa; First, Wally Bell; Second, Jim Wolf; Third, Ted Barrett.

T?2:30. A?30,315 (39,500).

White Sox 3, Rays 1

Tampa Bay Chicago

ab r h bi ab r h bi

Fuld lf 2 0 0 0 De Aza cf-lf 4 0 1 0

CGmnz c 0 0 0 0 Youkils 3b 4 0 1 1

BUpton cf 4 0 0 0 A.Dunn dh 3 0 0 0

Zobrist ss 3 1 1 1 Konerk 1b 4 0 1 0

Longori 3b 3 0 0 0 Rios rf 4 2 3 1

Scott dh 3 0 1 0 Przyns c 4 0 0 0

SRdrgz ph-dh 0 0 0 0 Viciedo lf 3 0 0 0

Kppngr 2b 3 0 1 0 Wise cf 1 0 0 0

C.Pena 1b 2 0 0 0 AlRmrz ss 3 0 2 1

BFrncs ph 1 0 0 0 Bckhm 2b 3 1 2 0

Joyce rf 3 0 0 0

RRorts ph 1 0 0 0

Loaton c 2 0 0 0

DJnngs ph-lf 2 0 0 0

Totals 29 1 3 1 Totals 33 3 10 3

Tampa Bay 100 000 000?1

Chicago 001 101 00x?3

E?Hellickson (2). DP?Tampa Bay 1, Chicago 1. LOB?Tampa Bay 8, Chicago 7. 2B?De Aza (29), Rios (37). HR?Zobrist (19), Rios (25).

IP H R ER BB SO

Tampa Bay

Hellickson L,9-11 5 2-3 9 3 2 1 2

Howell 1-3 0 0 0 0 1

W.Davis 1 0 0 0 0 3

Badenhop 0 1 0 0 0 0

C.Ramos 1 0 0 0 0 1

Chicago

Floyd W,11-11 5 2 1 1 5 6

Crain H,10 2 2-3 1 0 0 0 4

Thornton 0 0 0 0 1 0

N.Jones H,7 1-3 0 0 0 0 0

Veal H,4 1-3 0 0 0 0 1

A.Reed S,29-33 2-3 0 0 0 0 0

Thornton pitched to 1 batter in the 8th.

Badenhop pitched to 1 batter in the 8th.

HBP?by Crain (Longoria). WP?Crain.

Umpires?Home, Chad Fairchild; First, Alfonso Marquez; Second, Tom Hallion; Third, Brian O?Nora.

T?3:08. A?25,264 (40,615).

Orioles 9, Red Sox 1

Boston Baltimore

ab r h bi ab r h bi

Pdsdnk cf 3 1 1 0 McLoth lf 4 1 1 0

Quiroz ph 1 0 0 0 Hardy ss 4 0 1 0

Ciriaco 3b 3 0 0 0 C.Davis rf 4 1 1 2

Pedroia 2b 1 0 0 1 AdJons cf 4 0 0 0

DeJess 2b 1 0 0 0 Thome dh 4 1 3 0

C.Ross rf 3 0 0 0 MrRynl 1b 3 2 1 0

Loney 1b 3 0 0 0 Machd 3b 4 2 2 1

Sltlmch dh 3 0 0 0 Flahrty 2b 4 2 2 5

Lvrnwy c 3 0 0 0 Tegrdn c 3 0 1 1

Nava lf 2 0 0 0

Iglesias ss 3 0 0 0

Totals 26 1 1 1 Totals 34 9 12 9

Boston 100 000 000?1

Baltimore 600 030 00x?9

E?Podsednik (1), Patton (1), Flaherty (3). DP?Boston 2, Baltimore 1. LOB?Boston 2, Baltimore 5. 2B?Mar.Reynolds (26), Machado (8), Flaherty (2). HR?C.Davis (29), Flaherty (6). SB?Pedroia (19). S?Ciriaco. SF?Pedroia.

IP H R ER BB SO

Boston

A.Cook L,4-11 1 5 6 6 3 0

Aceves 3 2-3 6 3 3 0 4

Beato 2 1-3 1 0 0 0 2

Bard 1 0 0 0 1 0

Baltimore

Tillman W,9-2 8 1 1 0 2 4

Patton 1 0 0 0 0 1

A.Cook pitched to 2 batters in the 2nd.

Balk?Aceves.

Umpires?Home, Manny Gonzalez; First, Greg Gibson; Second, Phil Cuzzi; Third, Gerry Davis.

T?2:23. A?33,518 (45,971).

Yankees 11, Blue Jays 4

New York Toronto

ab r h bi ab r h bi

Jeter ss 6 0 1 0 Lawrie 3b 3 0 1 0

ISuzuki rf 5 1 2 1 Rasms cf 5 1 1 1

Gardnr lf 0 0 0 0 Encrnc dh 3 1 0 0

AlRdrg 3b 5 1 1 0 Arencii c 5 0 1 0

Cano 2b 4 2 2 1 Lind 1b 4 1 2 2

Swisher 1b 4 2 2 2 YEscor ss 5 0 1 0

Grndrs cf 4 0 1 0 KJhnsn 2b 4 1 1 0

Ibanez lf 4 1 1 1 RDavis rf 4 0 4 0

Dickrsn lf-rf 0 1 0 0 Gose lf 4 0 1 1

RMartn c 4 1 2 3

ErChvz dh 3 2 1 2

Totals 39 11 13 10 Totals 37 4 12 4

New York 210 004 112?11

Toronto 000 011 200? 4

E?Carreno (1). DP?New York 2, Toronto 1. LOB?New York 8, Toronto 11. 2B?I.Suzuki (27), Swisher (34), Granderson (18), Lawrie (26), Y.Escobar (21), K.Johnson (19), R.Davis (24), Gose (7). HR?R.Martin (20), Er.Chavez (15), Rasmus (23), Lind (11). SB?I.Suzuki (28).

IP H R ER BB SO

New York

Kuroda W,15-11 5 1-3 10 2 2 2 4

D.Phelps 1 2-3 1 2 2 1 1

D.Robertson 1 1 0 0 1 1

Eppley 2-3 0 0 0 0 1

R.Soriano 1-3 0 0 0 1 0

Toronto

Jenkins L,0-3 3 2-3 4 3 3 3 2

Cecil 2 1 2 2 0 2

Frasor 0 3 2 2 1 0

Carreno 1 2 1 1 1 0

Beck 1 1 1 1 0 0

Loup 1-3 1 0 0 0 0

Korecky 1 1 2 2 1 0

Frasor pitched to 4 batters in the 6th.

HBP?by Cecil (Cano). WP?Kuroda.

Umpires?Home, Paul Schrieber; First, Mike Everitt; Second, Laz Diaz; Third, Tim Welke.

T?3:43. A?25,785 (49,260).

Indians 8, Royals 5

Kansas City Cleveland

ab r h bi ab r h bi

Bourgs cf 4 0 1 0 Choo rf 4 1 2 2

Lough ph 1 0 0 0 CPhlps dh 5 0 3 1

TAreu ss 5 0 0 0 Kipnis 2b 4 0 1 3

AGordn lf 4 2 3 0 CSantn c 4 0 0 0

Butler 1b 4 2 2 2 Canzler lf 5 1 2 0

S.Perez c 4 1 2 2 Rottino lf 0 0 0 0

Francr rf 4 0 0 0 Ktchm 1b 5 0 0 0

Mostks 3b 4 0 1 0 Chsnhll 3b 5 1 3 1

AMoore dh 3 0 1 1 Lillirdg ss 3 2 2 0

B.Pena ph-dh 1 0 0 0 Carrer cf 4 3 3 1

Giavtll 2b 4 0 1 0

Totals 38 5 11 5 Totals 39 8 16 8

Kansas City 010 002 020?5

Cleveland 031 220 00x?8

E?Moustakas (15), Kotchman (6). DP?Kansas City 2. LOB?Kansas City 6, Cleveland 11. 2B?Butler (31), A.Moore (1), Choo 2 (42), Chisenhall (4). HR?Butler (29). SB?Kipnis (31). CS?Bourgeois (4).

IP H R ER BB SO

Kansas City

W.Smith L,6-9 3 9 6 6 2 2

Teaford 3 6 2 2 0 1

Mazzaro 1 1-3 1 0 0 1 0

G.Holland 2-3 0 0 0 0 2

Cleveland

D.Huff W,3-0 6 8 3 3 0 5

C.Allen 1 0 0 0 0 0

Maine 0 3 2 2 0 0

J.Smith H,21 1 0 0 0 0 0

C.Perez S,39-43 1 0 0 0 0 0

Maine pitched to 3 batters in the 8th.

W.Smith pitched to 2 batters in the 4th.

HBP?by Teaford (Lillibridge). PB?C.Santana.

Umpires?Home, Marvin Hudson; First, Toby Basner; Second, John Tumpane; Third, Tim McClelland.

T?3:00. A?14,850 (43,429).

National League

East Division

z-Washington 95 62 .605 ?

z-Atlanta 91 66 .580 4

Philadelphia 78 79 .497 17

New York 73 84 .465 22

Miami 67 90 .427 28

Central Division

x-Cincinnati 95 62 .605 ?

St. Louis 85 72 .541 10

Milwaukee 80 77 .510 15

Pittsburgh 76 81 .484 19

Chicago 59 98 .376 36

Houston 52 105 .331 43

West Division

x-San Francisco 92 65 .586 ?

Los Angeles 82 75 .522 10

Arizona 79 78 .503 13

San Diego 74 83 .471 18

Colorado 62 95 .395 30

z-clinched playoff berth

x-clinched division

Friday

Cincinnati 1, Pittsburgh 0

Miami 2, Philadelphia 1

N.Y. Mets 3, Atlanta 1

Houston 7, Milwaukee 6

St. Louis 12, Washington 2

Arizona 8, Chicago Cubs 3

San Francisco 3, San Diego 1

L.A. Dodgers 8, Colorado 0

Today

Cincinnati (Leake 8-9) at Pittsburgh (McPherson 0-2), 1:05 p.m.

Houston (Keuchel 3-7) at Milwaukee (Estrada 4-7), 1:10 p.m.

N.Y. Mets (C.Young 4-8) at Atlanta (Minor 10-10), 1:10 p.m.

Philadelphia (Halladay 10-8) at Miami (Nolasco 12-12), 1:10 p.m.

Washington (Zimmermann 12-8) at St. Louis (Lohse 16-3), 1:15 p.m.

Chicago Cubs (Germano 2-9) at Arizona (Cahill 12-12), 2:10 p.m.

San Francisco (Bumgarner 16-10) at San Diego (Stults 7-3), 2:35 p.m.

Colorado (Chatwood 5-5) at L.A. Dodgers (Blanton 9-13), 3:10 p.m.

Giants 3, Padres 1

San Francisco San Diego

ab r h bi ab r h bi

Pagan cf 5 0 0 0 EvCarr ss 4 0 0 0

Scutaro 2b 2 1 1 0 Venale rf 4 1 2 0

Theriot 2b 3 0 2 0 Headly 3b 4 0 1 0

Sandovl 3b 4 0 1 2 Alonso 1b 4 0 1 1

Arias pr-3b 0 0 0 0 Denorfi lf 3 0 0 0

Posey c 4 1 2 0 Kotsay ph 1 0 1 0

Pence rf 4 0 1 1 Maybin cf 3 0 0 0

Nady lf 3 0 1 0 Grandl ph 1 0 1 0

GBlanc pr-lf 0 0 0 0 JoBakr c 2 0 1 0

Belt 1b 4 0 0 0 Guzmn ph-2b 2 0 0 0

BCrwfr ss 4 0 1 0 Parrino 2b 2 0 0 0

Vglsng p 2 1 1 0 Thtchr p 0 0 0 0

Mijares p 0 0 0 0 Brach p 0 0 0 0

FPegur ph 0 0 0 0 Quentin ph 1 0 0 0

A.Huff ph 1 0 0 0 Werner p 0 0 0 0

Affeldt p 0 0 0 0 Bass p 1 0 0 0

JaLopz p 0 0 0 0 Thayer p 0 0 0 0

SCasill p 0 0 0 0 Solis ph-c 1 0 0 0

Totals 36 3 10 3 Totals 33 1 7 1

San Francisco 012 000 000?3

San Diego 000 001 000?1

E_Belt (8), B.Crawford (18), Solis (1). DP_San Francisco 1, San Diego 1. LOB_San Francisco 10, San Diego 7. 2B_Sandoval (24), Posey (38), Jo.Baker (8). 3B_Posey (1), Nady (1). SB_Theriot (13), Arias (5), G.Blanco (25). CS_Denorfia (4). S_Werner.

IP H R ER BB SO

San Francisco

Vogelsong W,14-9 6 5 1 0 1 4

Mijares H,7 1 0 0 0 0 1

Affeldt H,16 1 0 0 0 0 1

Ja.Lopez H,17 1-3 0 0 0 0 0

S.Casilla S,25-31 2-3 2 0 0 0 0

San Diego

Werner L,2-3 4 2-3 8 3 3 1 2

Bass 1 1-3 1 0 0 0 1

Thayer 1 1 0 0 1 1

Thatcher 2-3 0 0 0 1 2

Brach 1 1-3 0 0 0 1 3

WP_Werner.

Umpires_Home, Fieldin Culbreth; First, Adrian Johnson; Second, Gary Cederstrom; Third, Lance Barksdale.

T_3:12. A_32,691 (42,691).

Astros 7, Brewers 6

Houston Milwaukee

ab r h bi ab r h bi

Altuve 2b 5 1 2 1 Aoki rf 4 0 0 0

SMoore rf 3 0 0 0 RWeks 2b 4 1 0 0

BBarns cf 1 0 0 0 Braun lf 4 1 1 2

Lowrie ss 5 0 1 0 ArRmr 3b 3 0 1 1

Maxwll cf-rf-lf 5 0 0 0 Hart 1b 4 0 0 0

Wallac 1b 4 2 2 1 Mldnd c 3 0 0 0

JCastro c 3 3 2 2 FrRdrg p 0 0 0 0

FMrtnz lf 4 1 1 0 Loe p 0 0 0 0

Wrght p 0 0 0 0 LSchfr ph 1 1 1 0

R.Cruz p 0 0 0 0 CGomz cf 4 1 1 1

WLopez p 0 0 0 0 Segura ss 4 1 3 1

Dmngz 3b 4 0 2 2 Gallard p 1 0 0 0

EGnzlz p 2 0 1 1 Ishikaw ph 1 1 1 0

Ambriz p 0 0 0 0 Hndrsn p 0 0 0 0

Bogsvc ph-rf 1 0 0 0 Lucroy ph-c 2 0 0 0

Farris pr 0 0 0 0

Totals 37 7 11 7 Totals 35 6 8 5

Houston 010 220 011?7

Milwaukee 001 002 012?6

E?Dominguez (1), Segura 2 (9). DP?Houston 1, Milwaukee 1. LOB?Houston 6, Milwaukee 4. 2B?F.Martinez (7), Braun (35), Segura (3). 3B?Ar.Ramirez (3). HR?Altuve (7), Wallace (9), J.Castro 2 (5), C.Gomez (18). SB?Braun (30), Segura (7).

IP H R ER BB SO

Houston

E.Gonzalez W,3-1 5 2-3 4 3 3 0 3

Ambriz H,3 1 1-3 1 0 0 1 0

W.Wright H,18 2-3 0 1 1 1 1

R.Cruz 0 1 0 0 0 0

W.Lopez S,9-12 1 1-3 2 2 1 0 1

Milwaukee

Gallardo L,16-9 6 8 5 4 3 5

Henderson 1 0 0 0 0 2

Fr.Rodriguez 1 2 1 1 0 0

Loe 1 1 1 1 0 1

R.Cruz pitched to 1 batter in the 8th.

WP?E.Gonzalez.

Umpires?Home, Rob Drake; First, Andy Fletcher; Second, Joe West; Third, Mike Muchlinski.

T?3:15. A?41,716 (41,900).

Reds 1, Pirates 0

Cincinnati Pittsburgh

ab r h bi ab r h bi

BPhllps 2b 4 1 2 0 Presley lf 4 0 0 0

Cozart ss 4 0 2 0 Mercer 2b-ss 3 0 0 0

Votto 1b 3 0 1 0 AMcCt cf 2 0 0 0

Frazier lf 3 0 0 1 GJones 1b 3 0 0 0

Heisey lf 0 0 0 0 Tabata rf 2 0 0 0

Bruce rf 4 0 0 0 Snider ph-rf 1 0 0 0

Rolen 3b 3 0 2 0 PAlvrz 3b 3 0 0 0

Stubbs cf 3 0 0 0 Barmes ss 2 0 0 0

Hanign c 3 0 0 0 Clemnt ph 1 0 0 0

HBaily p 3 0 0 0 dArnad 2b 0 0 0 0

Barajs c 2 0 0 0

Holt ph 1 0 0 0

AJBrnt p 2 0 0 0

Watson p 0 0 0 0

McKnr ph 1 0 0 0

Totals 30 1 7 1 Totals 27 0 0 0

Cincinnati 100 000 000?1

Pittsburgh 000 000 000?0

E?Rolen (10). DP?Pittsburgh 2. LOB?Cincinnati 4, Pittsburgh 1. SB?A.McCutchen (20). CS?A.McCutchen (12). SF?Frazier.

IP H R ER BB SO

Cincinnati

H.Bailey W,13-10 9 0 0 0 1 10

Pittsburgh

A.J.Burnett L,16-9 8 7 1 1 1 5

Watson 1 0 0 0 0 0

WP?A.J.Burnett.

Umpires?Home, Ed Hickox; First, Chris Conroy; Second, Mark Carlson; Third, Angel Hernandez.

T?2:28. A?34,796 (38,362).

Diamondbacks 8, Cubs 3

Chicago Arizona

ab r h bi ab r h bi

DeJess cf 3 1 0 0 Eaton cf 4 1 3 1

Sappelt rf 5 1 1 2 Pollock lf 4 0 1 1

Rizzo 1b 4 0 0 0 A.Hill 2b 4 2 2 1

ASorin lf 1 1 1 0 J.Upton rf 4 2 2 2

SCastro ss 4 0 3 1 Ransm 3b 4 1 1 1

Valuen 3b 4 0 1 0 Nieves c 4 0 0 0

WCastll c 4 0 0 0 Jacobs 1b 2 1 0 0

Barney 2b 3 0 0 0 JMcDnl ss 4 0 1 1

T.Wood p 2 0 0 0 IKnndy p 0 1 0 0

Cardns ph 1 0 0 0 Albers p 0 0 0 0

Corpas p 0 0 0 0 Lndstr p 0 0 0 0

Russell p 0 0 0 0 GParra ph 1 0 0 0

LaHair ph 1 0 0 0 DHrndz p 0 0 0 0

JChpm p 0 0 0 0 RWhelr ph 0 0 0 0

Belivea p 0 0 0 0 CYoung ph 0 0 0 0

Putz p 0 0 0 0

Totals 32 3 6 3 Totals 31 8 10 7

Chicago 000 021 000?3

Arizona 100 130 03x?8

E?Barney (3). DP?Arizona 1. LOB?Chicago 9, Arizona 6. 2B?S.Castro (27), Valbuena (20), Eaton (3), Pollock (3), A.Hill 2 (42). HR?Sappelt (2), J.Upton (16), Ransom (11). SB?J.Upton (17). CS?Eaton (3). S?Eaton, Pollock.

IP H R ER BB SO

Chicago

T.Wood L,6-13 5 5 5 5 3 2

Corpas 1 0 0 0 0 1

Russell 1 1 0 0 0 0

J.Chapman 2-3 3 3 3 1 1

Beliveau 1-3 1 0 0 1 1

Arizona

I.Kennedy W,15-11 5 2-3 4 3 3 6 5

Albers H,2 1 2 0 0 1 0

Lindstrom H,3 1-3 0 0 0 0 1

D.Hernandez H,25 1 0 0 0 0 2

Putz 1 0 0 0 0 1

Umpires?Home, Mike Estabrook; First, Larry Vanover; Second, Dan Bellino; Third, Jerry Layne.

T?3:04. A?28,463 (48,633).

Marlins 2, Phillies 1

Philadelphia Miami

ab r h bi ab r h bi

Rollins ss 4 0 1 1 GHrndz cf 3 0 1 0

Frndsn 3b 4 0 0 0 Cousins ph 1 0 0 0

Utley 2b 4 0 0 0 Cishek p 0 0 0 0

Ruiz c 4 0 1 0 Petersn lf-cf 4 1 1 0

Wggntn 1b 3 0 2 0 Reyes ss 4 0 0 0

Howard ph 1 0 0 0 Stanton rf 3 1 2 1

Lindlm p 0 0 0 0 Ca.Lee 1b 4 0 1 1

Ruf lf 3 0 1 0 DSolan 2b 3 0 1 0

L.Nix ph-lf 0 0 0 0 J.Buck c 2 0 0 0

Mayrry rf-1b 4 1 1 0 Velazqz 3b 3 0 0 0

Mrtnz cf 3 0 1 0 Buehrle p 2 0 0 0

Cl.Lee p 2 0 0 0 Dobbs ph-lf 0 0 0 0

Kratz ph 1 0 0 0

Aumont p 0 0 0 0

Schrhlt rf 0 0 0 0

Totals 33 1 7 1 Totals 29 2 6 2

Philadelphia 000 000 010?1

Miami 000 100 001?2

One out when winning run scored.

DP?Philadelphia 1. LOB?Philadelphia 6, Miami 5. 2B?Mayberry (24), Petersen (8), Stanton (30). HR?Stanton (35). S?J.Buck.

IP H R ER BB SO

Philadelphia

Cl.Lee 7 3 1 1 0 5

Aumont 1 1 0 0 1 1

Lindblom L,3-4 1-3 2 1 1 1 0

Miami

Buehrle 8 6 1 1 0 8

Cishek W,5-2 1 1 0 0 1 2

Umpires?Home, Brian Knight; First, Tim Timmons; Second, Dale Scott; Third, Mark Wegner.

T?2:22. A?28,201 (37,442).

Cardinals 12, Nationals 2

Washington St. Louis

ab r h bi ab r h bi

Werth rf 3 0 0 0 Jay cf 5 2 2 0

CBrwn rf 1 0 0 0 MCrpnt 3b-1b 3 3 1 1

Harper cf 3 1 2 0 Hollidy lf 3 1 0 1

DeRosa 3b 1 0 0 0 SRonsn pr-lf 1 1 1 2

Zmrmn 3b 3 0 1 0 Craig 1b 4 2 4 2

CGarci p 0 0 0 0 RJcksn ph-2b 1 0 0 0

TMoore lf 0 0 0 0 YMolin c 3 2 1 3

LaRoch 1b 3 0 1 1 Chamrs rf 1 0 0 0

Tracy 1b 1 0 0 0 Beltran rf 1 0 0 1

Morse lf 3 0 0 0 Rosnthl p 0 0 0 0

Duke p 0 0 0 0 Salas p 0 0 0 0

EPerez ph 1 0 0 0 Descals 2b-3b 3 0 0 1

McGnzl p 0 0 0 0 Kozma ss 4 0 1 1

Dsmnd ss 3 0 1 0 Wnwrg p 3 0 0 0

Lmrdzz 2b 1 0 0 0 J.Kelly p 0 0 0 0

Espinos 2b-ss 4 0 0 0 T.Cruz c 1 1 1 0

KSuzuk c 2 0 0 0

Flores c 2 0 0 0

EJcksn p 0 0 0 0

Grzlny p 0 0 0 0

Berndn ph-cf 2 1 1 1

Totals 33 2 6 2 Totals 33 12 11 12

Washington 100 000 100? 2

St. Louis 540 000 03x?12

E?Zimmerman (19). DP?Washington 3. LOB?Washington 8, St. Louis 5. 2B?Harper (24), Zimmerman (35), Jay (20), M.Carpenter (22), T.Cruz (9). HR?Bernadina (5), S.Robinson (3), Y.Molina (22). SF?Descalso.

IP H R ER BB SO

Washington

E.Jackson L,9-11 1 1-3 6 9 8 4 0

Gorzelanny 2 2-3 1 0 0 2 2

C.Garcia 2 1 0 0 0 2

Duke 1 0 0 0 0 0

Mic.Gonzalez 1 3 3 3 0 0

St. Louis

Wainwright W,14-13 6 5 1 1 1 5

J.Kelly 1 1 1 1 1 2

Rosenthal 1 0 0 0 1 0

Salas 1 0 0 0 1 1

HBP?by C.Garcia (Holliday). WP?E.Jackson 2.

Umpires?Home, Bill Welke; First, Cory Blaser; Second, Chris Guccione; Third, Jeff Nelson.

T?2:51. A?39,166 (43,975).

Dodgers 8, Rockies 0

Colorado Los Angeles

ab r h bi ab r h bi

Rutledg ss 4 0 1 0 M.Ellis 2b 5 0 2 0

Colvin cf 4 0 1 0 L.Cruz 3b 5 0 1 0

Pachec 1b 4 0 0 0 Kemp cf 3 0 0 0

WRosr c 4 0 1 0 AdGnzl 1b 4 1 1 0

Nelson 3b 4 0 1 0 HRmrz ss 3 1 0 0

McBrid rf 4 0 0 0 Ethier rf 4 3 3 1

ABrwn lf 1 0 0 0 Victorn lf 4 1 2 3

LeMahi 2b 3 0 1 0 A.Ellis c 3 1 2 1

Francis p 1 0 0 0 Kershw p 2 0 0 0

Blckmn ph 1 0 0 0 BAreu ph 1 1 1 2

Moscos p 1 0 0 0 Wall p 0 0 0 0

Roenck p 0 0 0 0

WHarrs p 0 0 0 0

Totals 31 0 5 0 Totals 34 8 12 7

Colorado 000 000 000?0

Los Angeles 040 100 03x?8

DP?Colorado 1, Los Angeles 1. LOB?Colorado 6, Los Angeles 6. 2B?W.Rosario (19), M.Ellis (20), Ethier (34), A.Ellis (20). HR?Victorino (11), B.Abreu (3). S?Kershaw.

IP H R ER BB SO

Colorado

Francis L,5-7 4 6 5 5 1 3

Moscoso 2 2 0 0 1 1

Roenicke 1 0 0 0 0 1

W.Harris 1 4 3 3 0 2

Los Angeles

Kershaw W,13-9 8 5 0 0 2 10

Wall 1 0 0 0 0 1

HBP?by Francis (A.Ellis). WP?W.Harris 2.

Umpires?Home, Todd Tichenor; First, Brian Gorman; Second, Vic Carapazza; Third, Tony Randazzo.

T?2:46. A?37,133 (56,000).

Mets 3, Braves 1

New York Atlanta

ab r h bi ab r h bi

Tejada ss 4 0 1 0 RJhnsn cf 4 0 0 0

DnMrp 2b 3 1 1 0 Prado lf 3 0 0 0

DWrght 3b 4 0 0 0 Heywrd rf 4 0 1 0

I.Davis 1b 3 1 1 0 C.Jones 3b 4 0 0 0

Hairstn cf-lf 4 0 0 0 FFrmn 1b 4 1 1 1

Bay lf 0 0 0 0 Uggla 2b 2 0 1 0

Duda lf 3 1 2 3 D.Ross c 4 0 0 0

Acosta p 0 0 0 0 Smmns ss 3 0 1 0

Hmpsn p 0 0 0 0 THudsn p 2 0 0 0

FLewis ph 1 0 0 0 Pstrnck ph 1 0 0 0

Parnell p 0 0 0 0 CMrtnz p 0 0 0 0

Baxter rf 3 0 1 0 Gearrin p 0 0 0 0

Thole c 3 0 0 0

Niese p 1 0 0 0

Vldspn ph 0 0 0 0

AnTrrs cf 0 0 0 0

Totals 29 3 6 3 Totals 31 1 4 1

New York 000 000 300?3

Atlanta 000 100 000?1

DP?Atlanta 2. LOB?New York 3, Atlanta 6. 2B?Tejada (25), Dan.Murphy (39). HR?Duda (15), F.Freeman (23). CS?Baxter (3). S?Niese.

IP H R ER BB SO

New York

Niese W,13-9 7 4 1 1 3 3

Acosta H,2 1-3 0 0 0 0 1

Hampson H,1 2-3 0 0 0 0 1

Parnell S,6-11 1 0 0 0 0 1

Atlanta

T.Hudson L,16-7 7 5 3 3 1 4

C.Martinez 1-3 1 0 0 2 0

Gearrin 1 2-3 0 0 0 0 1

Umpires?Home, Kerwin Danley; First, Paul Nauert; Second, Dana DeMuth; Third, Doug Eddings.

T?2:31. A?51,910 (49,586).

Source: http://hawaiitribune-herald.com/sections/sports/procollege/major-league-baseball-standingsbox-scores.html-3

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Reese Witherspoon Welcomes a Baby Boy!

The actress and hubby Jim Toth are celebrating the birth of their first child together! Plus, see more stars who welcomed new bundles of joy

Source: http://www.ivillage.com/celebrity-babies-2011/1-b-16266?dst=iv%3AiVillage%3Acelebrity-babies-2011-16266

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Montinore Crush Party, Harvest Century Family Bike Ride, Festival ...

The beautiful fall weather shows no sign of letting up, and there's plenty to do outside and inside. Washington County Weekend is here to show you where the action is.

2012 Montinore Crush Party: Enjoy live music, grape-stomp competition, freshly pressed juice or wine tasting, The Fried Onion Food Cart, lawn games and more. The third annual event is family-friendly and free. Noon to 4 p.m. Saturday, Montinore Estate, 3663 S.W. Dilley Road, Forest Grove. Directions: 503-359-5012, ext. 2.

Festival Japan: The Beaverton grocery Uwajimaya will celebrate Japanese culture and community. There will be food, music and taiko drums, martial arts demonstrations, dance, arts and crafts, children's games and more. The free festival runs 11 a.m. to 5 p.m. Saturday and Sunday, 10500 S.W. Beaverton-Hillsdale Highway, Beaverton. Their website has the complete schedule.

Harvest Century Bike Ride: This 10th annual cycling event is a fundraiser for Community Vision. Choice of courses includes a disabled-accessible three-mile family route, plus 45-, 75- and 100-mile courses. Family ride is free; registration fee for longer courses is $65. Starts 2:30 p.m. Sunday at Tom Hughes Civic Center Plaza, 150 E. Main St., Hillsboro.
?
OOM-PAH!: It's McMenamin's Grand Lodge Oktoberfest, with lots of German food and drink and authentic polka and accordion music. Starts 1 p.m. Saturday, Grand Lodge, 3505 Pacific Ave., Forest Grove. 503-992-9533.

Painters Showcase: More than 30 artists will display their works at this 38th annual art exhibit and sale. Proceeds benefit Camp Rivendale, a summer program for persons with disabilities. Admission $5. Saturday reception is from 1 to 3 p.m. Sale hours are 10 a.m. to 5 p.m. Friday, Saturday and Sunday. Jenkins Estate, 8005 S.W. Grabhorn Road, Aloha.
?
Apple Harvest Festival: View old-fashioned toys, apple press and peelers from the 1880s. Family quilts will be assessed by an expert. No admission but donations "cheerfully accepted." Refreshments are 50 cents a bowl for apple cobbler and ice cream. Festival is from 1 to 4 p.m. Saturday, John Tigard House, 103rd Avenue and Canterbury Lane, Tigard. 503-747-9856
?
King City Lions Fundraiser: This event is a fundraiser for those residents who live in the 97224 Zip code and need hearing aids and glasses. There will be senior service providers present, plus food and wine samples. Cost $15. 2 to 5 p.m. Sunday at the King City Civic Association clubhouse, 15245 S.W. 116th Ave. 503-431-6750

Tualatin River History Day: Learn more about the Tualatin River from local historians, photographs and multimedia presentation. Presented by Winona Grange and Tualatin Riverkeepers. Free; 2 to 5 p.m. Sunday, Winona Grange, 8340 S.W. Seneca St., Tualatin.

"Sherwood: Tales From the Attic" book signing: Learn new things about the city's history from recently published author June Reynolds. 10 a.m. Saturday, fireplace area, Sherwood Public Library, 22560 S.W. Pine St.

Dragonslayer Bike, Hike or Trike: The NW Sarcoma Foundation has organized a family-friendly 5K walk/bike ride to raise awareness, support and research funding for patients and their families. Includes music, raffle and activities for the family. Registration: 9 a.m. Event: 10 a.m. to noon Saturday, Cook Park, 17005 S.W. 92nd Ave., Tigard. Cost $20-$35 to walk/bike, free for activities.

Camelot: Hark back to the times of King Arthur and the Knights of the Round Table when this play, presented by Beaverton Civic Theatre, opens this weekend. Showtimes are 8 p.m. tonight and Saturday, with a Sunday matinee at 2 p.m. Beaverton City Library auditorium, 12375 S.W. Fifth St. Box office: 503-754-9866.
?
Of Mice and Men: Hillsboro theater company Bag & Baggage presents this John Steinbeck drama set in the 1937 Dust Bowl storm. 7:30 p.m. showtimes Friday through Sunday, The Venetian Theatre, 253 E. Main St., Hillsboro. 503-345-9590

-- The Oregonian

Source: http://www.oregonlive.com/washingtoncounty/index.ssf/2012/09/montinore_crush_party_harvest.html

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B2B Marketing Innovation: What B2B Marketers Can Learn From ...

Posted on 27. Sep, 2012 by Lee Odden in B2B, B2B content marketing, Blog, interview, interviews, Marketing PR Conferences, marketingprofs, Small Business Internet Marketing, Small Business Marketing

Customer preferences for information discovery, consumption and engagement have evolved in a way that requires marketers to adapt. In particular, B2B marketers have had to find new and innovative ways to communicate with customers over long sales cycles filled with digital distractions from smartphones, tablets, computers and other connected devices.? Content types are equally diverse and can range from videos to white papers to infographics and even cartoons.

Tom Fishburne is the Founder and CEO of the wildly popular Marketoonist?and?in this interview, he?ll share a sneak peek into his B2B Marketing Forum presentation, the importance of storytelling, deciding on visual content and his prediction on the future of B2B Marketing and innovation.

We?re big fans of your work! ?Please describe how you become a ?Marketoonist?. ?Did your journey really start with doodling on?business?cases at Harvard?

Thanks! Harvard Business School isn?t exactly a feeder school for cartoonists.? I?d dreamed of being a cartoonist when I was a kid, but I?d let it go.? In business school, I started doodling again on the backs of business cases, then in the school paper, and pretty soon professors started asking me for cartoons to use as teaching aids.

I knew that cartoons were powerful communication devices, but I never saw cartooning as a potential career, so I worked in marketing after business school, at General Mills, Nestle, and Method Products.? I kept drawing cartoons on the side, sending them once a week to my marketing co-workers in a simple email newsletter.? Ten years later, my marketing cartoon reaches over 100,000 readers a week.

I thought about submitting cartoons to the New Yorker and the Wall Street Journal, which are two of the main cartoon markets.? But then, the Wall Street Journal contacted me.? They asked if I could create a 20-page cartoon book to help communicate with their readers on how to get the most out of the Journal.? It dawned on me that my unique combination of marketer and cartoonist (Marketoonist) could be valuable to others.

Two years ago, I started Marketoon Studios full-time to develop cartoon-based content marketing campaigns.? I work with a variety of B2B companies, including Oracle, Vodafone, Kronos, and Guidance Software to help them connect and engage with their audiences, using the unexpected medium of cartoons.

What are you most excited about when it comes to B2B marketing?

There has never been a better time to work in marketing. The shift in the role of marketers as publishers is particularly exciting, because it elevates our role to become thought leaders, rather than just pitching features and benefits and parroting our single-minded propositions.

At the MarketingProfs B2B Marketing Forum?next week you?re presenting ?Content Worth Sharing: What B2B Marketers Can Learn From Cartoons?. What are 2-3 of the most important takeaways from your presentation? What can people attending expect to learn?

With all of the technology at our disposal as marketers, we sometimes forget the value of the big marketing idea. Technology is only as valuable as the marketing ideas that the technology enables.? We can?t make an antisocial experience social just by adding social media.?? Technology can?t save a boring idea, but it can amplify a remarkable one.? The impetus is on marketers to create marketing worth sharing.

Another main point is the power of preaching to the choir.? It?s a misnomer that to be a big organization, we have to try to talk to everyone in our marketing.? One size actually fits none.? The more niche we get in our communication strategy, the more powerful the bond we create with our audience.? It?s better to be deeply appealing to a few than blandly appealing to the great majority.

One of my favorite sayings in marketing/sales is ?Facts tell, stories sell?. What advice can you share about the importance of storytelling with?B2B?marketing?

I completely agree with that sentiment.? Features and benefits are boring.? There is no longer a captive audience in marketing.? Without a story, it is easier than ever for our audiences to tune out our messages altogether.? In B2B marketing in particular, brand communication is frequently fact and feature-based.? There is a tremendous amount of power in telling stories when everyone else is telling facts.

The growing appeal of visual content has provided B2B marketers even more opportunities to attract, engage and convert prospects to customers across the buying cycle. What advice can you give companies that are trying to decide what kind of visual content or media is right for them and their target audience?

I think of visual content as Trojan horses.?? It?s most important that it breaks through the clutter and that the audience lets it in.? This means it can?t come off as an advertorial.? But it?s also key that it convey some meaning about your brand.? With our marketoon campaigns, the topics that we parody in a cartoon somehow link so the problems that that brand is trying to solve.? The brand proposition for Kronos is that ?workforce management doesn?t have to be so hard?.? So every marketoon parodies situations where workforce management has historically been ?hard?.? The audience sees the humor in the situations, and the Kronos brand comes along for the ride.

Developing a solid?B2B?marketing plan takes research, an understanding of customer goals, pain points and journey.? What are some of the most common myths or mistakes you?ve seen with B2B marketing planning?? Any tips on how to be more successful?

Don?t be a one hit wonder.? Many businesses take a ?Flock of Seagulls? approach to B2B marketing.? They create one piece of media and hope that it ?goes viral?. If it doesn?t, they often give up.? The web is full of ?social media ghost towns? from B2B brands that have given up.? What?s far more important than virality is continuity.? Commit to the long haul in how we connect and engage with our consumers, rather than the one-off campaign.

With all the hype in the business marketing media, it?s tempting for companies to chase trending?B2B?marketing tactics. What tips can you share that will help marketers convince management on the importance of creativity, experimentation and innovation??

Chasing the shiny new thing is a real challenge for marketers.? It feels sometimes like the tail is wagging the dog.? Many campaigns are built around the tactic of the week, as if the tactic alone was the big idea.? The advice I would give marketers is to stay focused on the big ideas, and remember that the tactics are enablers to those big ideas.? Creativity and experimentation are needed to bring the big ideas to life.? That?s a better sell to management, and ultimately leads to better executions with customers too.

Any predictions on the future of B2B marketing and the role of visual content?

I think that B2B marketing will become much more interesting in the future as we move beyond the hype of new technologies, and focus more on the big ideas that can be enabled by those technologies.? We can engage with our customers in more meaningful ways.? Technology amplifies great marketing.?? I think that visual content will play an increasing role in the marketing we want to amplify.

Please share a tip on how companies can come up with new and innovative ideas for their B2B marketing efforts.

Whether B2C or B2B, the most important shift in marketing is that brand communication is no longer a one-way command-and-control megaphone.? It?s a conversation.? Don Draper is no longer in charge of our brands.? Our audiences are in charge.? So the best inspiration for our marketing efforts comes from our audiences themselves.? Our goal should be, not to market how awesome our products and services are, but figuring out how to make our audiences more awesome.

Thank you for your insights Tom!

If you?re looking for even more insight on making your business more innovative, ?be sure to attend Tom?s solo presentation at B2B Marketing Forum ?Content Worth Sharing: What B2B Marketers Can Learn From Cartoons??Friday, October 5th at 8:15am.

Sadly, this is the same time as my Track Keynote on Integrating Search, Social and Content across they Buying Cycle but regardless of which presentation you see, you?ll get great info . This is why you should bring 2 or more people to the B2B Forum, so your team can attend multiple sessions scheduled at the same time!

We?ll be releasing a B2B Marketing Innovation eBook on Friday 9/28 that?s chock full of B2B Marketing Innovation tips from marketing champions like IBM, SAP and Silverpop, so be sure to check back!

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Tags: B2B Marketing Forum, marketoonist, online marketing, Small Business Internet Marketing, Tom Fishburne

Source: http://www.frontlinemarketingsystems.com/blog/small-business-marketing/b2b-marketing-innovation-what-b2b-marketers-can-learn-from-cartoons-with-tom-fishburne/

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Libya leader to NBC: Film not behind consulate attack

In an exclusive interview with NBC News' Ann Curry, Libyan President Mohamed Magarief says he has "no doubt" the attack on the U.S. Consulate in Benghazi was pre-planned.

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By NBC News staff

Updated at 4:01 a.m. ET: An anti-Islam film that sparked violent protests in many countries had?"nothing to do with" a?deadly attack on the U.S. Consulate in Benghazi earlier this month, Libya's president told NBC News.

In an exclusive interview with NBC News'?Ann Curry, President Mohamed Magarief discounted claims that the attack was in response to a movie produced in California and available on YouTube. He noted that the assault happened on Sept. 11 and that the video had been available for months before that.

"Reaction should have been, if it was genuine, should have been six months earlier. So it was postponed until the 11th of September," he said. "They chose this date, 11th of September to carry a certain message."

NYT: Deadly Libya attack a major blow to CIA efforts

Magarief said there were no protesters at the site before the attack, which he noted came in two assaults, first with rocket-propelled grenades on the consulate, then with mortars at a safe house.

Khaled Abdullah / Reuters

Protests ignited by a controversial film that ridicules Islam's Prophet Muhammad spread throughout Muslim world.

The attack took the lives of Ambassador Chris Stevens, as well as information management officer Sean Smith and security personnel Tyrone Woods and Glen Doherty.

US Ambassador Chris Stevens was 'courageous,' Obama says

Magarief told Curry that based on the accuracy of the assault, he believes the attackers must have had training and experience using the weapons.

"It's a pre-planned act of terrorism," he said, adding that the anti-Islam film had "nothing to do with this attack."

'A strong friend'
Magarief said that while Libyans appeared to be behind the attack that "these Libyans do not represent the Libyan people or Libyan population in any sense of the word."

Hilary Stevens, sister of Christopher Stevens, the U.S. Ambassador to Libya who died Tuesday during an attack on the U.S. consulate in Benghazi. In an interview with Rock Center Anchor Brian Williams, Stevens reflects on her brother's legacy and work.

He added: "We consider the United States as a friend, not only a friend, a strong friend, who stood with us in our moment of need."

More than 40 people have been questioned in connection with the incident,?the Libyan leader?told Curry.

He described Stevens as a "humble and very unique human being" and a "great friend of Libya."

Thousands of Libyans stormed the headquarters of an Islamist militia group in Benghazi Friday night in a deadly exchange. NBC's Ayman Mohyeldin reports.

Backlash: Protesting Libyans storm militant compound

The Obama administration initially maintained that the attacks were directly linked to protests over the film. Speaking on NBC?s ?Meet the Press? on Sept. 16, U.S. Ambassador to the United Nations Susan Rice said: ?What happened in Benghazi was in fact initially a spontaneous reaction to what had just transpired hours before in Cairo, almost a copycat of the demonstrations against our facility in Cairo, prompted by the video.?

However, White House Press Secretary Jay Carney last week said it was "self-evident that what happened in Benghazi was a terrorist attack."

Slain ambassador's mom: 'He was trying to do something much bigger'

Speaking before the United Nations General Assembly on Tuesday, President Barack Obama said: ?There are no words that excuse the killing of innocent? people.

On Tuesday, President Obama spoke to the United Nations general assembly in an emotional speech about the recent violence against Americans. NBC's Chuck Todd reports.

More world stories from NBC News:

Follow World News from NBCNews.com on Twitter and Facebook

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Source: http://worldnews.nbcnews.com/_news/2012/09/26/14105135-libyan-president-to-nbc-attack-on-us-consulate-was-pre-planned-act-of-terrorism?lite

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Shared Resort Real Estate Ownership 2012: a Market Perspective ...

The ownership of shared resort real estate has become a preferred way to vacation for millions of Americans, according to the latest national research commissioned by Interval International, a prominent worldwide provider of vacation services. Among the findings: an estimated 12 million adults now own what is commonly referred to as ?timeshare,? and among the most appealing attributes associated with shared ownership is the ability to exchange, cited by eight in ten current owners.

These findings are from the newly-released Shared Resort Real Estate Ownership 2012: A Market Perspective, which is being distributed at the 14th Annual Shared Ownership Investment Conference held September 18 ? 20, in Orlando, Florida. The survey was conducted by MMGY Global with a nationally-representative sample of 810 active leisure travelers who met specific criteria with respect to their age and annual household income.

?The observations of this report, when viewed through the lens of current shared resort real estate owners, as well as non-owners who are interested in purchasing, will enable developers to compete more effectively in the broader lodging and hospitality sector,? said Peter C. Yesawich, Ph.D., vice chairman of MMGY Global.

?The implications suggest that the preferred product offerings and services will continue to evolve with the shifting social values of today?s leisure travelers. The results also reveal that the concept of shared ownership aligns well with marketplace trends, which bodes well for continued industry growth.?

?We believe this study will be extremely useful to developers and marketers since it examines the changing travel habits, preferences, and intentions of current and prospective owners. It provides valuable insights, such as those relating to price points and product characteristics, that indicate how the industry may need to evolve,? added Bryan Ten Broek, Interval?s senior vice president of resort sales and business development for North America.

Notable Findings

• Leisure travelers interested in purchasing shared resort real estate tend to be married (63%) and average 42 years of age. Approximately four in 10 report having children who live in their household full time.
• Leisure travelers interested in purchasing shared resort real estate took an average of just over three (3.4) leisure trips during the past 12 months, and spent an estimated $1,730 on lodging accommodations.
• Eight in 10 leisure travelers who are current owners (80%), and a comparable percentage of prospective purchasers (84%), prefer a beach or lake experience on vacation.
• Nearly nine in 10 prospective purchasers are interested in staying at a condominium-style resort during the next two years.
• Mini-vacations and weekends at shared ownership resorts are, by far, the most highly rated incentives to participate in a sales tour, with eight in 10 leisure travelers who are prospective purchasers (83%) citing their appeal.

The data for this study were collected during June and July 2012 using a nationally representative panel of U.S. consumers, prequalified and screened for specific demographic and behavioral characteristics. Respondents were adults who: took at least one trip for leisure purposes of at least 75 miles away from home that required overnight accommodations during the previous year; were between 25 and 64 years of age; and reported a minimum annual household income of $50,000.

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Joe Hickman, the Asia Pacific Executive Director of Interval International & Preferred Residences will be attending the AOCAP Conference and taking part in two seminars (listed below) on the second day of the conference.

Joseph Hickman ? Executive Director Asia Pacific, Interval International & Preferred Residences

Joe Hickman has held the position of executive director for Interval International Asia-Pacific based in Singapore for over seven years.? He has responsibility for implementing business development activities for Asia-Pacific, including affiliating resorts with Preferred Residences and Interval International?s global network, developing and directing all sales and resort marketing strategies, as well as managing developer client relationships.

Hickman has lived and worked in Asia for well over twenty years and has spent his entire professional career in the hospitality and timeshare industries. ?He has amassed experience in a broad range of areas including sales and marketing, finance, resort services, business development and call center operations.? Prior to Interval International he served as the area director/vice president for HMC Asia Pacific, which specializes in hotel club programs. ?He lead the marketing efforts and pre-opening for both the Conrad Hong Kong and Shangri-La Hotel Kuala Lumpur and for several years, directed the sales and marketing efforts of the Westin Philippine Plaza, Manila and International Sales and Marketing for Westin?s Bonaventure Hotel in Los Angeles. ?Mr. Hickman served as International Director of Sales/Marketing for Hilton?s Conrad Hotel Division prior to taking on responsibility for marketing of Hilton Grand Vacations Club (HGVC) in Las Vegas. ?His responsibilities included all marketing and lead generation for HGVC?s first purpose-built 200-unit timeshare resort in Las Vegas.? He also served as corporate director for vacation ownership for Hilton Hotels and was part of the team that pioneered Hilton?s early entry into the timeshare business.

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11:15 ? 12:10
THE NEED FOR A REGIONAL TRADE ASSOCIATION
Hear the views of Industry Leaders from a number of different jurisdictions regarding the vital role and importance of a well supported regional Trade Association and how various legislative frameworks around the region have impacted the industry.
Moderator: Howard Nusbaum,?President and Chief Executive Officer, American Resort Development Association [ARDA]
Panelists: Ramy Filo, CEO, Classic Holidays, Queensland, Australia
Khor Poh Waa (to be confirmed)
Joe Hickman,?Executive Director Asia Pacific, Interval International, Singapore

14:30 ? 15:15
EMERGING TRENDS IN MARKETING, SALES AND DISTRIBUTION
A panel of Innovators will provide some insights into new marketing and distribution channels which can be used within the Shared Ownership Industry in order to reach your target markets cost-effectively; the session will also feature some highly innovative concepts related to accommodations.?
Moderator: Joe Hickman, Executive Director Asia Pacific, Interval International, Singapore
Panelists: Roger Searl, CEO, Millionaire Asia
Simon Squibb, CEO, Loft, Hong Kong
Mark Greedy, CEO, Elite Resorts of Asia-Pacific

Source: http://www.aocap.org/shared-resort-real-estate-ownership-2012-a-market-perspective/

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Oil extends losses as economy pessimism persists

BANGKOK (AP) ? The price of oil fell below $91 a barrel Wednesday in Asia, tracking stock markets which dropped on renewed pessimism about the outlook for economic growth.

Benchmark crude was down 62 cents to $90.75 a barrel at midafternoon Bangkok time in electronic trading on the New York Mercantile Exchange. The contract dropped 56 cents to settle at $91.37 a barrel Tuesday in New York.

Oil failed to get an enduring boost from an improvement in U.S. consumer confidence to its highest level since February. Markets were overshadowed by comments from Charles Plosser, president of the U.S. Federal Reserve's Philadelphia branch, indicating that the Fed's efforts to support the world's biggest economy would likely fall short of its goals.

The comments reinforced the current pessimism about growth prospects, and dragged down stocks on Wall Street and then Asia. Benchmark crude has fallen from near $100 since the middle of last month. Energy prices tend to fall when growth is slow because of lower demand.

The U.S. economy is growing slowly. There also are concerns that Europe's debt crisis will continue to weigh on the global economy. China's export-driven economy has cooled off, largely due to Europe's problems.

Brent crude was down 65 cents at $109.80 a barrel on the ICE futures exchange in London.

In other energy futures trading on the New York Mercantile Exchange:

? Heating oil was down 1.2 cents at $3.095 a gallon.

? Wholesale gasoline gained 0.7 cent to $2.83.

? Natural gas gained 2.6 cents to $2.95 per 1,000 cubic feet.

Source: http://news.yahoo.com/oil-extends-losses-economy-pessimism-persists-073427736.html

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PETA calls for wider acknowledgement of IOM report on chimpanzee research

Public release date: 26-Sep-2012
[ | E-mail | Share ]

Contact: Justin Goodman
JustinG@peta.org
860-882-2492
People for the Ethical Treatment of Animals

Group says some ignoring implications of landmark findings

In a new letter published in the journal Blood, People for the Ethical Treatment of Animals (PETA) calls for greater diligence by the scientific community to ensure that new papers reporting experiments on chimpanzees acknowledge the Institute of Medicine's landmark 2011 report "Chimpanzees in Biomedical and Behavioral Research: Assessing the Necessity." The IOM concluded that, "most current biomedical research use of chimpanzees is not necessary."

The letter responded to an article in Blood reporting a study in which two chimpanzees were infected with Hepatitis C, a disease area in which the IOM did not deem chimpanzee use necessary. The authors did not mention the IOM report or its findings. Since the publication of the IOM report in December 2011, numerous other journals have published disease studies on chimpanzees that do not mention the relevant IOM findings.

In the Blood letter, PETA Associate Director of Laboratory Investigations Justin Goodman stated, "Authors, peer-reviewers and editors must ensure that findings like those of the IOM are addressed in relevant manuscripts in order to prevent replication or extension of work that could subject additional chimpanzees to pain and distress when they have been deemed unnecessary to the research in question. One need not look any further than the IOM report to appreciate that experiments on chimpanzees have clearly continued despite having limited utility and the existence of valid alternatives."

A commentary by Goodman on the issue was also published in the Hastings Center's Bioethics Forum in July.

Following discussions with PETA, the Journal of Experimental Medicine and Gastroenterology have added editorial notes referencing the IOM report to recent manuscripts.

Earlier this month, PETA sent a letter to the National Institutes of Health's Working Group on the Use of Chimpanzees in NIH-Supported Research requesting that it issue a directive requiring that all publications reporting federally-funded experiments on chimpanzees acknowledge the IOM report, the conclusions of which NIH fully accepted.

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Link to full-text of Blood letter: http://bloodjournal.hematologylibrary.org/content/119/26/6326/reply#bloodjournal_el_7220

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[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 26-Sep-2012
[ | E-mail | Share ]

Contact: Justin Goodman
JustinG@peta.org
860-882-2492
People for the Ethical Treatment of Animals

Group says some ignoring implications of landmark findings

In a new letter published in the journal Blood, People for the Ethical Treatment of Animals (PETA) calls for greater diligence by the scientific community to ensure that new papers reporting experiments on chimpanzees acknowledge the Institute of Medicine's landmark 2011 report "Chimpanzees in Biomedical and Behavioral Research: Assessing the Necessity." The IOM concluded that, "most current biomedical research use of chimpanzees is not necessary."

The letter responded to an article in Blood reporting a study in which two chimpanzees were infected with Hepatitis C, a disease area in which the IOM did not deem chimpanzee use necessary. The authors did not mention the IOM report or its findings. Since the publication of the IOM report in December 2011, numerous other journals have published disease studies on chimpanzees that do not mention the relevant IOM findings.

In the Blood letter, PETA Associate Director of Laboratory Investigations Justin Goodman stated, "Authors, peer-reviewers and editors must ensure that findings like those of the IOM are addressed in relevant manuscripts in order to prevent replication or extension of work that could subject additional chimpanzees to pain and distress when they have been deemed unnecessary to the research in question. One need not look any further than the IOM report to appreciate that experiments on chimpanzees have clearly continued despite having limited utility and the existence of valid alternatives."

A commentary by Goodman on the issue was also published in the Hastings Center's Bioethics Forum in July.

Following discussions with PETA, the Journal of Experimental Medicine and Gastroenterology have added editorial notes referencing the IOM report to recent manuscripts.

Earlier this month, PETA sent a letter to the National Institutes of Health's Working Group on the Use of Chimpanzees in NIH-Supported Research requesting that it issue a directive requiring that all publications reporting federally-funded experiments on chimpanzees acknowledge the IOM report, the conclusions of which NIH fully accepted.

###

Link to full-text of Blood letter: http://bloodjournal.hematologylibrary.org/content/119/26/6326/reply#bloodjournal_el_7220

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-09/pfte-pcf092612.php

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Silicon Valley?s Next Great Company

Jack Dorsey, chairman of Twitter and CEO of Square

Photo by Bill Pugliano/Getty Images.

Ever since Facebook went public, people in Silicon Valley have been a bit bummed out about the tech industry. Keep in mind that the Valley is infinitely optimistic, so even when they?re bummed, folks here keep smiling. Still, in numerous conversations over the past few months, I?ve detected a sense of gloom, and it?s obvious why.

Social networking had long been hailed as the next big thing, a revolutionary tech that promised to change the world and rake in big money, too. While it?s still promising, Facebook?s dismal stock performance (not to mention that of related companies like Zynga) has cooled the industry on big, ad-sponsored consumer websites. Meanwhile, Google is trying to figure out what it wants to do with its future, while Apple, the tech world?s engine of hardware innovation, feels less exciting than it did when the iPhone and iPad were new products. So far, there?s no sign that Tim Cook?s company is interested in pursuing anything more than incremental, hyper-profitable annual updates to its product lineup (not that there?s anything wrong with that).

The Valley likes to anoint standard-bearers, companies whose amazing, unreasonable success points to sunny days ahead. Before Facebook, everyone was gaga for Google, and before Google there were all those dot-coms. Now there?s a hole in the industry?s crystal ball. There?s no consensus on which company will define the next era of technology.

I believe the tech industry?s next great company is Square. If you?ve heard of Jack Dorsey?s three-year-old firm, you likely think of it as a payments startup. Square is famous for its white plastic card reader, a device that lets small businesses use phones and tablets to accept credit cards. But calling Square a mere payments company minimizes its potential, and it misses Dorsey?s world-changing mission.

If you study Square?s products and its pricing, and if you talk to Dorsey about his plans, you?ll find that the company?s real mission is to alter the psychology of consumption. Dorsey is bent on creating frictionless commerce. His long-term goal is to make accepting payments a breeze for businesses, and he wants to make paying for stuff invisible?for everyone, across the entire economy, for all types of goods and services. If Square succeeds in that mission, it will become a persistent, ever-present part of our daily lives. You?ll use it every time you engage with businesses?which might mean you?ll interact with Square more often than Google, Facebook, Amazon, or even Apple.

I spoke to Dorsey and Keith Rabois, Square?s chief operating officer, at the company?s gleaming San Francisco office last month. I?d come to chat about two recent announcements that won lots of headlines, but whose combined effects haven?t really been appreciated by the tech press. In August, Square announced that, beginning this fall, it will process all credit card payments at Starbucks stores. When the system is fully up and running, customers will be able to shop at Starbucks just by saying their names: After you opt in, your name and photo will pop up on the Starbucks cashier?s screen when you enter the store with your phone in your pocket. To pay, you?ll just tell the cashier to put it on your tab. That?s it?you don?t have to remove your phone or swipe or sign anything.

A few weeks after the Starbucks deal, Square dropped the other shoe. The company had long charged businesses a 2.75 percent fee to process payments through Square, which is less than most credit card processing companies ask for. But now Square has made the deal even better, rolling out a flat fee of $275 per month. The price applies to transactions under $400 on the first $250,000 in a business?s yearly sales, which means that the fee can be as low as 1.3 percent. Businesses that go over the $400-per-item or $250,000-per-year limits pay 2.75 percent on those transactions; the 2.75 fee is also still available for businesses with a low volume of monthly credit transactions. ?The basic premise of the program is we wanted to remove any excuse for not taking credit,? Rabois says. ?There is no longer any excuse for an American business to not accept credit cards today?they're handicapping their own sales and profits if they don?t, and their customers will be happier if they do.?

Taken together, the Starbucks deal and the monthly pricing plan address what had been Square?s greatest problem?the chicken-and-egg hurdle that all online marketplaces face when starting out. Square?s pay-by-name system will only achieve its potential if lots of stores accept it, but stores have little incentive to sign up with Square if there aren?t a lot of customers clamoring to pay that way. These two announcements solve both sides of the puzzle. The Starbucks collaboration will introduce millions of new customers to the magic of paying with Square, while the new pricing plan will give businesses a clear financial incentive to sign up. Once both sides get together, Square will be unstoppable.

Source: http://feeds.slate.com/click.phdo?i=7dee080922868769de51d218615a1380

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Rochester's deaf population among largest per capita in U.S. (Rochester Democrat and Chronicle)

Share With Friends: | | Politics - Top Stories Stories, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/250996184?client_source=feed&format=rss

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