new technology gadget: Cancer/testis antigens are novel targets of ...

Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma.

Blood. 2012 Feb 8;

Authors: Nishikawa H, Maeda Y, Ishida T, Gnjatic S, Sato E, Mori F, Sugiyama D, Ito A, Fukumori Y, Utsunomiya A, Inagaki H, Old LJ, Ueda R, Sakaguchi S

Abstract

Adult T-cell leukemia/lymphoma (ATLL) is an intractable hematologic malignancy caused by human T-lymphotropic virus type 1 (HTLV-1), which infects approximately 20 million people worldwide. Here, we have explored the possible expression of cancer/testis (CT) antigens by ATLL cells, as CT antigens are widely recognized as ideal targets of cancer immunotherapy against solid tumors. A high percentage (87.7%) of ATLL cases (n=57) expressed CT antigens at the mRNA level; NY-ESO-1 (61.4%), MAGE-A3 (31.6%), and MAGE-A4 (61.4%). CT antigen expression was confirmed by immunohistochemistry. This contrasts with other types of lymphoma or leukemia, which scarcely express these CT antigens. Humoral immune responses, particularly against NY-ESO-1, were detected in 11.6% (5/43) and NY-ESO-1-specific CD8(+) T cell responses were observed in 55.6% (5/9) of ATLL patients. NY-ESO-1-specific CD8(+) T cells recognized autologous ATLL cells and produced effector cytokines. Thus, ATLL cells characteristically express CT antigens and therefore vaccination with CT antigens can be an effective immunotherapy of ATLL.

PMID: 22323448 [PubMed - as supplied by publisher]

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Source: http://medicine.journalfeeds.com/hematology/blood/cancertestis-antigens-are-novel-targets-of-immunotherapy-for-adult-t-cell-leukemialymphoma/20120211/

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Source: http://new-technology-gadget-blog.blogspot.com/2012/02/cancertestis-antigens-are-novel-targets.html

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